Réaction #1121781

Équation de réaction

231

2-Benzyl-8-(4-methoxyphenylthio)-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one

acetyl chloride

→

25a

Rendement 66.0%

2-Benzyl-8-(4-methoxyphenylthio)-6-phenylimidazo[1,2-a]pyrazin-3-yl acetate

Rendement 66.0%

Solvants

dichloromethane

Conditions de réaction

Traitement

1. 1
   LavageThen the solution was washed with water
2. 2
   Séchagethe organic layer was dried over Na2SO4
3. 3
   Filtrationfiltered
4. 4
   Autrethe solvent removed under reduced pressure

Mode opératoire

To a solution of 231 (25 mg, 0.06 mmol) in 4 mL of dichloromethane, acetyl chloride (8 μL, 0.12 mmol) and 4-(dimethylamino)pyridine (DMAP) (5 mg, 0.03 mmol) were added, the resulting mixture was stirred at room temperature for 15 min. Then the solution was washed with water and the organic layer was dried over Na2SO4, filtered and the solvent removed under reduced pressure to obtain 18 mg (yield 66%) of 25a as a red oil. 1H-NMR (CDCl3): 2.10 (s, 3H), 3.88 (s, 3H), 4.20 (s, 2H), 7.00-7.02 (m, 2H), 7.22-7.33 (m, 8H), 7.61-7.64 (m, 4H), 7.68 (s, 1H). MS (ESI): m/z 482 (M+H+).

Source