Réaction #1121

ord-54a1898a2ac34fa5a7bd7f2b4fc5d5b1

Équation de réaction

COc1nccc(N)c1OC
2,3-dimethoxy-4-aminopyridine
CC(C)(C)CC(C)(C)C1CCC(=O)CC1
4-(1,1,3,3-tetramethylbutyl)cyclohexanone
→
COc1nccc(N[C@H]2CC[C@@H](C(C)(C)CC(C)(C)C)CC2)c1OC
2,3-Dimethoxy-4-[cis-4-(1,1,3,3-tetramethylbutyl)cyclohexylamino]pyridine

Réactifs

COc1nccc(N)c1OC
2,3-dimethoxy-4-aminopyridine
CC(C)(C)CC(C)(C)C1CCC(=O)CC1
4-(1,1,3,3-tetramethylbutyl)cyclohexanone

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

As Example 75, but using 1.54 g (10 mmol) of 2,3-dimethoxy-4-aminopyridine instead of 2-ethyl-3-bromo-4-amino-pyridine and 4.2 g (20 mmol) of 4-(1,1,3,3-tetramethylbutyl)cyclohexanone instead of 4-phenylcyclohexanone.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US05723450uspto-grants-1998_03