Réaction #1120

ord-bbef73e40290461c80e983d0e34bab95

Équation de réaction

CCC1(N)CC=NC=C1Br
4-ethyl-4-amino-5-bromopyridine
CC(C)(C)CC(C)(C)C1CCC(=O)CC1
4-(1,1,3,3-tetramethylbutyl)cyclohexanone
CC(C)OC(C)C
diisopropyl ether
→
CCc1cc(N[C@H]2CC[C@@H](C(C)(C)CC(C)(C)C)CC2)c(Br)cn1
2-Ethyl-4-[cis-4-(1,1,3,3-tetramethylbutyl)cyclohexylamino]-5-bromopyridine

Réactifs

CCC1(N)CC=NC=C1Br
4-ethyl-4-amino-5-bromopyridine
CC(C)(C)CC(C)(C)C1CCC(=O)CC1
4-(1,1,3,3-tetramethylbutyl)cyclohexanone
CC(C)OC(C)C
diisopropyl ether

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

As Example 75, but using 2.01 g (10 mmol) of 4-ethyl-4-amino-5-bromopyridine instead of 2-ethyl-3-bromo-4-aminopyridine and 4.2 g (20 mmol) of 4-(1,1,3,3-tetramethylbutyl)cyclohexanone instead of 4-phenylcyclohexanone. Yield: 1.9 g (48%); Rf =0.39 (diisopropyl ether)

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US05723450uspto-grants-1998_03