Réaction #1107

Équation de réaction

4-(4-tert-butylanilino)-3-methoxy-2-methylpyridine

→

4-(4-tert-Butylcyclohexylamino)-3-methoxy-2-methylpyridine

Solvants

water

methanol

HCl

Conditions de réaction

Traitement

1. 1
   Autreare hydrogenated at room temperature
2. 2
   Autrenormal pressure until absorption of hydrogen
3. 3
   FiltrationAfter filtering
4. 4
   Concentrationconcentrating 1 g of syrup

Mode opératoire

1 g of 4-(4-tert-butylanilino)-3-methoxy-2-methylpyridine in 20 ml of methanol, 3.7 ml of 2N HCl and 1.3 ml of water are hydrogenated at room temperature and normal pressure until absorption of hydrogen has ended using 1 g of rhodium on alumina (5% strength). After filtering and concentrating 1 g of syrup remains=100% isomer mixture.

Source