Réaction #1106

Équation de réaction

4-chloro-3-methoxy-2-methylpyridine

4-tert-butylaniline

NaOH

→

4-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine

Solvants

phenol

Conditions de réaction

Traitement

1. 1
   TempératureAfter cooling
2. 2
   Extractionthe product is extracted
3. 3
   ConcentrationAfter concentrating
4. 4
   workup.DISTILLATIONthe excess of amine is distilled off in vacuo
5. 5
   Autrethe residue is crystallized

Mode opératoire

7.9 g of 4-chloro-3-methoxy-2-methylpyridine and 22.4 g of 4-tert-butylaniline are heated at 120° C. for 8 hours in 20 g of phenol. After cooling, the mixture is poured into NaOH and the product is extracted using methylene chloride. After concentrating, the excess of amine is distilled off in vacuo and the residue is crystallized using hexane. 9.5 g=55%

Source