Réaction #1102788

Équation de réaction

product

2-{[2-fluoro-6-(trifluoromethyl)benzoyl]amino}-4,4,6,6-tetramethyl-4,6-dihydrothieno[2,3-c]furan-3-carboxylic acid

propargylamine hydrochloride

→

title compound

2-{[2-fluoro-6-(trifluoromethyl)benzoyl]amino}-4,4,6,6-tetramethyl-N-prop-2-ynyl-4,6-dihydrothieno[2,3-c]furan-3-carboxamide

Conditions de réaction

Mode opératoire

The title compound was prepared from the product of Example 45A and commercially available propargylamine hydrochloride using the procedure described for Example 2B. 1H NMR (DMSO-d6, 300 MHz) δ 1.44 (s. 6H), 1.48 (s, 6H), 3.06-3.08 (m, 1H), 3.90-3.93 (m, 2H), 7.65-7.81 (m, 3H), 8.55 (t, J=5.6 Hz, 1H), 11.58 (br s, 1H). MS (ESI+) m/z 469 (M+H)+. Anal. calcd. for C22H20F4N2O3S: C, 56.40; H, 4.30; N, 5.98. Found: C, 56.36; H, 4.27; N, 5.94.

Source