Réaction #1100107

ord-abbd24cdbabb449baab03d1664403dee

Équation de réaction

CON(C)C(=O)[C@H]1CC[C@H](NC(=O)OC(C)(C)C)CC1
[trans-4-(methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester
O=Cc1ccc2c(c1)NC(=O)CO2
3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbaldehyde
CCOc1cccc2scnc12
4-ethoxy-benzothiazole
→
CCOc1cccc2sc(C(=O)[C@H]3CC[C@H](NCc4ccc5c(c4)NC(=O)CO5)CC3)nc12
title compound
CCOc1cccc2sc(C(=O)[C@H]3CC[C@H](NCc4ccc5c(c4)NC(=O)CO5)CC3)nc12
6-{[trans-4-(4-ethoxy-benzothiazole-2-carbonyl)-cyclohexylamino]-methyl}-4H-benzo[1,4]oxazin-3-one

Réactifs

CON(C)C(=O)[C@H]1CC[C@H](NC(=O)OC(C)(C)C)CC1
[trans-4-(methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester
—
1.c
O=Cc1ccc2c(c1)NC(=O)CO2
3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbaldehyde
CCOc1cccc2scnc12
4-ethoxy-benzothiazole

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

The title compound was prepared according to the same protocol as that described for example 1, steps 1.a to 1.c, starting from 4-ethoxy-benzothiazole (5 mmol), [trans-4-(methoxy-methyl-carbamoyl)-cyclohexyl]-carbamic acid tert-butyl ester (2.5 mmol) and 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbaldehyde (0.3 mmol). A yellowish solid (9 mg) was obtained.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07981886B2uspto-grants-2011_07