Réaction #1099222

Équation de réaction

2-[ethyl(phenyl)amino]ethanol

sulphuric acid

sodium nitrite

sulphuric acid

2-amino-4-chloro-1,3-thiazole-5-carbaldehyde

→

4-chloro-2-((E)-{4-[ethyl(2-hydroxyethyl)amino]phenyl}-diazenyl)-1,3-thiazole-5-carbaldehyde

Solvants

propionic acid

acetic acid

water

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGAfter stirring for another 2 hours at room temperature
2. 2
   Filtrationthe obtained precipitate was filtered off
3. 3
   Lavagewashed with water
4. 4
   Autredried at 40° C. in vacuum

Mode opératoire

1.3 g (18.56 mmol) sodium nitrite was added in small portions to 13.2 g conc. sulphuric acid and cooled to 0° C. and diluted with 4.8 ml propionic acid and 19.2 ml acetic acid. 3.0 g (18.45 mmol) 2-amino-4-chloro-1,3-thiazole-5-carbaldehyde were then added in small portions. The viscous reaction mixture was stirred for 2 hours at 0° C. This mixture was then added slowly to a solution of 3.2 g (18.56 mmol) 2-[ethyl(phenyl)amino]ethanol in 180 ml water, containing 6 ml sulphuric acid. After stirring for another 2 hours at room temperature, the obtained precipitate was filtered off, washed with water and dried at 40° C. in vacuum.

Source