Réaction #1095907

Équation de réaction

4,6-dichloro-5-fluoropyrimidine

3,5-dimethylpiperidine

→

4-chloro-6-(trans-3,5-dimethylpiperidino)pyrimidin

4-chloro-6-(cis-3,5-dimethyl piperidino)-5-fluoropyrimidine

Conditions de réaction

Mode opératoire

0.2 g of 4,6-dichloro-5-fluoropyrimidine and 0.41 g of 3,5-dimethylpiperidine (cis/trans diastereomer=about 3/1) were mixed and left for 30 minutes at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.1 g of 4-chloro-6-(cis-3,5-dimethyl piperidino)-5-fluoropyrimidine and 0.05 g of 4-chloro-6-(trans-3,5-dimethylpiperidino)pyrimidin.

Source