Réaction #1095880

Équation de réaction

ammonium chloride

4-(2-butynyloxy)-6-chloropyrimidine

potassium carbonate

3,3-dimethylpiperidine hydrochloride

→

4-(2-butynyloxy)-6-(3,3-dimethylpiperidino)pyrimidine

Rendement 95.1%

Solvants

acetonitrile

Conditions de réaction

Traitement

1. 1
   TempératureThe reaction mixture was cooled to near room temperature
2. 2
   Extractionthe mixture was extracted with tert-butyl methyl ether three times
3. 3
   LavageThe organic layers were washed with a saturated sodium chloride aqueous solution
4. 4
   Séchagedried over anhydrous magnesium sulfate
5. 5
   Concentrationconcentrated

Mode opératoire

Into 2 ml of acetonitrile were added 0.20 g of 4-(2-butynyloxy)-6-chloropyrimidine, 0.45 g of potassium carbonate and 0.20 g of 3,3-dimethylpiperidine hydrochloride, and the mixture was stirred for 2 hours at 80° C. The reaction mixture was cooled to near room temperature, a saturated ammonium chloride aqueous solution was added therein, and the mixture was extracted with tert-butyl methyl ether three times. The organic layers were washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to obtain 0.27 g of 4-(2-butynyloxy)-6-(3,3-dimethylpiperidino)pyrimidine (hereinafter, referred to as Compound (31)).

Source