Réaction #1095869

Équation de réaction

2-methylpiperidine

N,N-dimethylformamide

4-chloro-6-(2-butynyloxy)pyrimidine

potassium carbonate

→

4-(2-butynyloxy)-6-(2-methylpiperidino)pyrimidine

Rendement 27.0%

Solvants

ethyl acetate

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONwas added
2. 2
   TempératureThe reaction mixture was cooled to near room temperature
3. 3
   Lavagethe mixture was washed with a saturated sodium chloride aqueous solution three times
4. 4
   SéchageThe organic layers were dried over anhydrous magnesium sulfate
5. 5
   Concentrationconcentrated

Mode opératoire

Into 2 ml of N,N-dimethylformamide was resolved 183 mg of 4-chloro-6-(2-butynyloxy)pyrimidine, 166 mg of potassium carbonate and 99 mg of 2-methylpiperidine was added therein, and the mixture was stirred for 4 hours at 80° C. and 3 hours at 120° C. The reaction mixture was cooled to near room temperature, ethyl acetate was added therein, and the mixture was washed with a saturated sodium chloride aqueous solution three times. The organic layers were dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to obtain 66 mg of 4-(2-butynyloxy)-6-(2-methylpiperidino)pyrimidine (hereinafter, referred to as Compound (20)).

Source