Réaction #1077251

Équation de réaction

2-(3,4-methylenedioxy)phenyl-1-ethanol

acetic anhydride

→

1-acetoxy-2-[(3,4-methylenedioxy)phenyl]ethane

Rendement 81.0%

Solvants

pyridine

Conditions de réaction

Traitement

1. 1
   Autrethe resultant reaction mixture
2. 2
   Extractionwas extracted with ether (2×75 mL)
3. 3
   ExtractionThe combined ether extract
4. 4
   Lavagewas washed with water (2×50 mL), 5% Hcl (2×50 mL)
5. 5
   SéchageThe organic layer was dried over magnesium sulfate
6. 6
   Autrethe solvent was removed under reduced pressure

Mode opératoire

To a stirred solution of 2-(3,4-methylenedioxy)phenyl-1-ethanol (1.68 g, 10 mmol) in dry pyridine was added acetic anhydride and the resultant reaction mixture was stirred at 80° C. for 1 h. The reaction mixture was poured into ice-water and was extracted with ether (2×75 mL). The combined ether extract was washed with water (2×50 mL), 5% Hcl (2×50 mL) and then with 5% NaHCO3 (2×50 mL). The organic layer was dried over magnesium sulfate and the solvent was removed under reduced pressure to give 1-acetoxy-2-[(3,4-methylenedioxy)phenyl]ethane as a solid (1.7 g, 81% yield).

Source