Réaction #1077250

Équation de réaction

2-(3,4-methylenedioxy)phenylacetic acid

BH3THF

→

2-(3,4-methylenedioxy)phenyl-1-ethanol

Rendement 98.0%

Solvants

THF

Conditions de réaction

Traitement

1. 1
   AutreTHF was evaporated on a rotavap
2. 2
   workup.ADDITIONThe residue was treated with water (100 mL)
3. 3
   Extractionextracted with ether (2×100 mL)
4. 4
   AutreRemoval of the solvent under reduced pressure

Mode opératoire

To a solution of 2-(3,4-methylenedioxy)phenylacetic acid (5 g, 25.75 mmol) in anhydrous THF (20 mL) at 0° C. was added BH3THF (40 mL, 1.0 M in THF). The mixture was stirred at room temperature for 1 h. To work up, THF was evaporated on a rotavap. The residue was treated with water (100 mL) Acidified and extracted with ether (2×100 mL). Removal of the solvent under reduced pressure gave 2-(3,4-methylenedioxy)phenyl-1-ethanol as an oil (4.7 g, 98% yield).

Source