Réaction #10686

ord-68a2a3cab0e14ea68b8e17f3298801c9

Équation de réaction

O.O.[Cl][Sn][Cl]
tin(II) chloride dihydrate
O=[N+]([O-])c1cccc2c(O)ncc(Br)c12
Intermediate 137
O=[N+]([O-])c1cccc2c(O)ncc(Br)c12
1-hydroxy-4-bromo-5-nitroisoquinoline
Nc1cccc2c(O)ncc(Br)c12
title compound
Nc1cccc2c(O)ncc(Br)c12
1-hydroxy-4-bromo-5-aminoisoquinoline

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

According to the method of Example 114, Step A, a reduction reaction with tin(II) chloride dihydrate was performed by using Intermediate 137 to obtain the title compound.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07094789B2uspto-grants-2006_08