Réaction #10646

Équation de réaction

Tin(II) chloride dihydrate

Intermediate 89

4-chloro-5-nitroisoquinoline

sodium hydroxide

→

title compound

Rendement 67.5%

4-chloro-5-aminoisoquinoline

Rendement 67.5%

Solvants

hydrochloric acid

hydrochloric acid

Conditions de réaction

Traitement

1. 1
   Températurerefluxed
2. 2
   Températurewith heating for 2 hours
3. 3
   Extractionextracted twice with chloroform (20 ml for each time)
4. 4
   SéchageThe organic layer was dried over anhydrous sodium sulfate
5. 5
   Autrethe solvent was evaporated under reduced pressure

Mode opératoire

Tin(II) chloride dihydrate (1.70 g) was dissolved in concentrated hydrochloric acid (1 ml), added with a mixture of Intermediate 89 (315 mg) and 2 N aqueous hydrochloric acid (2 ml) with ice cooling and refluxed with heating for 2 hours. The reaction mixture was cooled to room temperature, added with 5 N aqueous sodium hydroxide (7 ml) and extracted twice with chloroform (20 ml for each time). The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to obtain the title compound (182 mg).

Source