Réaction #1045

Équation de réaction

2,3,3-trifluoro-2-propenyl bromide

triethyl phosphite

→

diethyl (1,1,2-trifluro-2-propenyl)phosphonate

Rendement 11.0%

diethyl (2,3,3-trifluro-2-propenyl)phosphonate

Rendement 14.0%

Conditions de réaction

Traitement

1. 1
   Températureat reflux for overnight
2. 2
   AutreThe residue obtained
3. 3
   Autreafter evaporation of the solvent
4. 4
   Autrewas chromatographed over silica gel (hexanes/ethyl acetate/ethanol, 80/20/1)

Mode opératoire

A solution of 2,3,3-trifluoro-2-propenyl bromide (5.25 g, 30 mmol) and triethyl phosphite (4.15 g, 25 mmol) in acetonltrile (15 mL) was heated at reflux for overnight. The residue obtained after evaporation of the solvent was chromatographed over silica gel (hexanes/ethyl acetate/ethanol, 80/20/1) to give diethyl (1,1,2-trifluro-2-propenyl)phosphonate (0.8 g, 11%) and diethyl (2,3,3-trifluro-2-propenyl)phosphonate (1.0 g, 14%).

Source