Réaction #1044

Équation de réaction

1,2,4-triazole

3,4,4-trifluoro-3-butenoyl chloride

→

desired product

Rendement 94.2%

1-(3,4,4-trifluoro-1-oxo-3-butenyl)-1H-1,2,4-triazole

Rendement 94.2%

Solvants

ethyl acetate

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGThe mixture was stirred for 30 min
2. 2
   Filtrationfiltered
3. 3
   AutreThe residue obtained
4. 4
   Autreafter evaporation of the solvent
5. 5
   workup.DISSOLUTIONwas redissolved in dichloromethane (25 mL)
6. 6
   Filtrationfiltered
7. 7
   AutreEvaporation of the solvent

Mode opératoire

To a solution of 1,2,4-triazole (1.38 g, 20 mmol) in ethyl acetate (100 mL) was added 3,4,4-trifluoro-3-butenoyl chloride (1.59 g, 10 mmol) at r.t. with stirring. The mixture was stirred for 30 min and filtered. The residue obtained after evaporation of the solvent was redissolved in dichloromethane (25 mL) and filtered. Evaporation of the solvent gave 1.8 g (94%) of the desired product as a dear oil.

Source