Réaction #1042

Équation de réaction

3,4,4-trifluoro-3-butenoyl chloride

2-amino-4,6-dimethoxypyrimidine

potassium carbonate

→

title compound

Rendement 10.7%

2-(3,4,4-trifluoro-1-oxo-3-butenyl)amino-4,6-dimethoxy-pyrimidine

Rendement 10.7%

Solvants

dichloromethane

water

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGThe reaction mixture was stirred in cold for 10 min
2. 2
   LavageThe organic layer was washed with 3N HCl (2×25 mL), saturated sodium bicarbonate (25 mL) and brine
3. 3
   Autredried
4. 4
   AutreEvaporation of the solvent

Mode opératoire

To an ice-cooled stirred suspension of 2-amino-4,6-dimethoxypyrimidine (1.55 g, 10 mmol) in dichloromethane (50 mL) and potassium carbonate (2.76 g, 20 mmol) in water (20 mL) was added 3,4,4-trifluoro-3-butenoyl chloride (3.17 g, 20 mmol). The reaction mixture was stirred in cold for 10 min and at r.t. for 15 min. The organic layer was washed with 3N HCl (2×25 mL), saturated sodium bicarbonate (25 mL) and brine, and dried. Evaporation of the solvent gave 0.296 g (10%) of the title compound as a white solid. m.p. 127°-130° C.

Source