Réaction #1029

Équation de réaction

2-acetyl-4-(pyrid-2-yl)-pyrimidine

hydroxylamine

sodium acetate

→

2-acetyl-4-(pyrid-2-yl)-pyrimidine oxime

Rendement 91.1%

Solvants

water

ethanol

water

Conditions de réaction

Traitement

1. 1
   Températurewas heated
2. 2
   Températureto reflux for 1.5 hours
3. 3
   Filtrationfiltered
4. 4
   Lavagewashed with hexane

Mode opératoire

A solution of 2-acetyl-4-(pyrid-2-yl)-pyrimidine (1.0 g), hydroxylamine (0.39 g) and sodium acetate (0.62 g) in a mixture of ethanol (10 ml) and water (2 ml) was heated to reflux for 1.5 hours. The reaction was then poured into water the precipitate filtered and washed with hexane to give 2-acetyl-4-(pyrid-2-yl)-pyrimidine oxime (0.98 g, 91% yield) as a white crystalline solid m.p. 196°-8° C.; 1H NMR: 2.50(3H,s); 7.42(1H,m); 7.88(1H,m); 8.30(1H,d); 8.59(1H,d); 8.74(1H,d); 8.90(1H,d); 10.85(1H,brs) ppm.

Source