Réaction #1011792

Équation de réaction

2-amino-3-bromo-5-chlorobenzoic acid

phosgene

→

desired product

Rendement 114.2%

8-Bromo-6-chloro-1H-benzo[d][1,3]oxazine-2,4-dione

Rendement 114.2%

Solvants

dioxane

Conditions de réaction

Traitement

1. 1
   Concentrationconcentrated in vacuo
2. 2
   AutreThe resulting solid was crushed
3. 3
   Autrefurther dried in vacuo

Mode opératoire

To a solution of 2-amino-3-bromo-5-chlorobenzoic acid (10.0 g, 39.9 mmol) in dioxane (170 mL) was added phosgene (20% in toluene, 42.0 mL, 79.9 mmol) over a period of 15 mins. The reaction was stirred at ambient temperature for 48 h and then concentrated in vacuo. The resulting solid was crushed and further dried in vacuo to yield the desired product (12.6 g, 114%) which was used in the subsequent step without further purification.

Source