Réaction #1005985

Équation de réaction

2-chloromethylquinoline hydrochloride

potassium carbonate

tert-butyl piperazine-1-carboxylate

→

2-(piperazin-1-ylmethyl)quinoline

Rendement 92.0%

Solvants

acetone

Conditions de réaction

Traitement

1. 1
   AutreReaction
2. 2
   Filtrationfiltered through celite
3. 3
   ConcentrationFiltrate was concentrated on Rotavapor under vacuum
4. 4
   Autrethe crude residue was purified on SiO2 using Biotage SP1

Mode opératoire

To a solution of 2-chloromethylquinoline hydrochloride (5 mmol) in anhydrous acetone (100 mL) was added, anhydrous potassium carbonate (15 mmol) and tert-butyl piperazine-1-carboxylate (7 mmol) and the reaction mixture was stirred under reflux conditions for 12 h. Reaction was cooled to r.t. and filtered through celite. Filtrate was concentrated on Rotavapor under vacuum and the crude residue was purified on SiO2 using Biotage SP1 to give a pure 2-(piperazin-1-ylmethyl)quinoline (6.3, 92%, pale yellow solid).

Source