Réaction #1005983

Équation de réaction

Compound 47

N-(4-chlorobutyl)-N-methyl-4-phenyl-1H-imidazole-1-carboxamide

tetra-n-butylammonium azide

→

N-(4-azidobutyl)-N-methyl-4-phenyl-1H-imidazole-1-carboxamide

Solvants

acetone

Conditions de réaction

Traitement

1. 1
   Températurethe reaction was refluxed for 8 h
2. 2
   Autresolvent was evaporated on Rotavapor
3. 3
   Autreto give a crude compound which
4. 4
   Autreon purification by Biotage SP1

Mode opératoire

Compound 47 (4.3) (1 mmol) was taken in anhydrous acetone (25 mL) and tetra-n-butylammonium azide (2 mmol) was added and the reaction was refluxed for 8 h. The reaction was cooled to RT and solvent was evaporated on Rotavapor to give a crude compound which on purification by Biotage SP1 provided pure N-(4-azidobutyl)-N-methyl-4-phenyl-1H-imidazole-1-carboxamide (48/4.4).

Source