Réaction #1005975

Équation de réaction

6-methoxy-2,2-dimethyl-thiochroman-4-one

BBr3

→

6-hydroxy-2,2-dimethylthiochroman-4-one

Rendement 40.0%

Solvants

CH2Cl2

CH2Cl2

Conditions de réaction

Traitement

1. 1
   Températurewas cooled to −78° C.
2. 2
   Autrequenched by the slow addition of 50 mL of H2O
3. 3
   TempératureUpon warming to room temperature the aqueous layer
4. 4
   Extractionwas extracted with CH2Cl2
5. 5
   Lavagethe combined organic layers were washed with saturated aqueous NaHCO3, H2O, and saturated aqueous NaCl
6. 6
   Séchagebefore being dried over MgSO4
7. 7
   AutreRemoval of the solvents under reduced pressure
8. 8
   Autregave a green-brown solid which
9. 9
   Autreupon recrystallization (Et2O/hexanes)

Mode opératoire

To a solution of 6-methoxy-2,2-dimethyl-thiochroman-4-one (6.0 g, 27 mmol) in 50 mL CH2Cl2 cooled to −23° C. was added BBr3 (20.0 g, 80.0 mmol; 80.0 mL of a 1M solution in CH2Cl2) over a 20 minute period. After stirring for 5 hours at −23° C. the solution was cooled to −78° C. and quenched by the slow addition of 50 mL of H2O. Upon warming to room temperature the aqueous layer was extracted with CH2Cl2 and the combined organic layers were washed with saturated aqueous NaHCO3, H2O, and saturated aqueous NaCl before being dried over MgSO4. Removal of the solvents under reduced pressure gave a green-brown solid which upon recrystallization (Et2O/hexanes) afforded 2.25 g (40%) of 6-hydroxy-2,2-dimethylthiochroman-4-one as a light brown solid. 1H NMR (300 MHz, CDCl3) δ: 7.63 (1H, d, J=2.8 Hz), 7.15 (1H, d, J=8.5 Hz), 7.01 (1H, dd, J=2.8, 8.5 Hz), 2.87 (2H, s), 1.46 (6H, s).

Source