Réaction #1005973

Équation de réaction

levothyroxine sodium

mannitol

propyl gallate

sucrose

→

Levothyroxine

Solvants

water

—

alcohol

Conditions de réaction

Traitement

1. 1
   Autremilled
2. 2
   workup.ADDITIONwere added over about 10 minutes
3. 3
   AutreThe wet granulation was dried at a temperature below 60° C. until the moisture content

Mode opératoire

The microcrystalline cellulose, mannitol, and sucrose were screened or milled and then blended with levothyroxine sodium for about 6 minutes. Acacia, dissolved in water, and propyl gallate, dissolved in alcohol, were added over about 10 minutes to granulate the mixture. The wet granulation was dried at a temperature below 60° C. until the moisture content was less than about 4%. The dried granulation was sized by passing it through a mill, and then blended with the additional ingredients listed in the table below using conventional mixing equipment.

Source