Réaction #1005957

Équation de réaction

5-Bromoindan-1-one

Hydroxylammonium chloride

sodium acetate

→

5-bromo-N-hydroxyindan-1-imine

Rendement 95.2%

Solvants

methanol

water

Conditions de réaction

Traitement

1. 1
   Extractionextracted twice with ethyl acetate
2. 2
   Lavagewashed with water
3. 3
   Séchagedried over anhydrous magnesium sulfate
4. 4
   FiltrationThe desiccant was filtered
5. 5
   Autreseparated
6. 6
   Autrethe solvent was evaporated off under reduced pressure

Mode opératoire

5-Bromoindan-1-one (5.0 g) was dissolved in methanol. Hydroxylammonium chloride (2.5 g) and sodium acetate (2.9 g) were added to the solution at room temperature, and then stirred overnight. The reaction solution was diluted with water and extracted twice with ethyl acetate. The organic layers were combined, washed with water, and dried over anhydrous magnesium sulfate. The desiccant was filtered and separated, and then the solvent was evaporated off under reduced pressure to obtain 5-bromo-N-hydroxyindan-1-imine (5.1 g).

Source