Réaction #1005947

Équation de réaction

Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate

3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidine

potassium carbonate

→

title compound

Rendement 95.0%

ethyl 2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-pyrrolidin-1-yl]-4-(trifluoromethyl)pyrimidine-5-carboxylate

Rendement 95.0%

Solvants

N,N-dimethylformamide

Conditions de réaction

Traitement

1. 1
   TempératureAfter cooling
2. 2
   Extractionextracted with ethyl acetate
3. 3
   SéchageThe organic layer was dried over magnesium sulfate
4. 4
   AutreThe solvent was evaporated off under reduced pressure
5. 5
   Autrethe residue was then purified by a silica gel chromatography

Mode opératoire

Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (1.2 g) [see J. Med. Chem., 43, 3995 (2000)], 3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidine (1.5 g), and potassium carbonate (0.7 g) were added to N,N-dimethylformamide (50 mL) and the mixture was heated at 100° C. for 5 hours. After cooling, the reaction solution was poured over ice water, and then extracted with ethyl acetate. The organic layer was dried over magnesium sulfate. The solvent was evaporated off under reduced pressure, and the residue was then purified by a silica gel chromatography to obtain the title compound (2.4 g, 95%).

Source