Réaction #1005944

Équation de réaction

3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)pyrrolidine

4-fluoro-2-trifluoromethylbenzonitrile

potassium carbonate

N,N-dimethylformamide

→

title compound

Rendement 42.5%

4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoromethyl)-benzonitrile

Rendement 42.5%

Solvants

ethyl acetate

Conditions de réaction

Traitement

1. 1
   TempératureAfter cooling the mixture to room temperature
2. 2
   Lavagewashed with water three times
3. 3
   SéchageThe organic layer was dried over anhydrous magnesium sulfate
4. 4
   AutreThe solvent was evaporated off under reduced pressure
5. 5
   Autrethe residue was then purified by a column chromatography

Mode opératoire

3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)pyrrolidine (5.6 g), 4-fluoro-2-trifluoromethylbenzonitrile (4.5 g) and potassium carbonate (5.4 g) were added to N,N-dimethylformamide (50 mL), and the mixture was stirred at 110° C. for 4 hours. After cooling the mixture to room temperature, the solution was diluted with ethyl acetate and washed with water three times. The organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated off under reduced pressure, and the residue was then purified by a column chromatography to obtain the title compound (3.8 g).

Source