Réaction #1003499

Équation de réaction

154BG85-11

4-fluoronaphthalene-1-carboxylic acid ethyl ester

pyrrolidine

→

title compound

Rendement 70.0%

4-Pyrrolidin-1-ylnaphthalene-1-carboxylic acid ethyl ester

Rendement 70.0%

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONwas added
2. 2
   AutreThe tube was capped
3. 3
   Autrethe reaction tube was exposed to microwave irradiation (100° C., 3 min)
4. 4
   AutreThe pyrrolidine was evaporated
5. 5
   Autrethe reaction mixture was transferred to a separation funnel with ethyl acetate
6. 6
   Lavagewashed with 2 M NaOH
7. 7
   Extractionextracted with ethyl acetate
8. 8
   AutreThe organic phases were collected
9. 9
   Séchagedried over Na2SO4
10. 10
    Filtrationfiltered
11. 11
    Concentrationconcentrated

Mode opératoire

154BG85-11 (156 mg, 0.7 mmol) was transferred to a Pyrex tube and pyrrolidine (1 mL) was added. The tube was capped and the reaction tube was exposed to microwave irradiation (100° C., 3 min). The microwave exposure was repeated for 5 min at 130° C. The pyrrolidine was evaporated and the reaction mixture was transferred to a separation funnel with ethyl acetate and washed with 2 M NaOH. The aqueous phase was acidified with 2 M HCl and extracted with ethyl acetate. The organic phases were collected, dried over Na2SO4, filtered and concentrated to yield 135 mg (70%) of the title compound.

Source