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CC[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3cc(F)cc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3C=O)cn(C)c2=O)nc1
Reaction #494820
111g
Rendement 35.2%DOI: 10.6084/m9.figshare.5104873.v1
CC[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3ccnc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3C=O)cn(C)c2=O)nc1
Reaction #494822
112a
Rendement 49.0%DOI: 10.6084/m9.figshare.5104873.v1
CC[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3cc(F)cc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3COC(C)=O)cn(C)c2=O)nc1
Reaction #606521
114g
Rendement 39.0%DOI: 10.6084/m9.figshare.5104873.v1
CC[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3cc(F)cc(-n4ccn5c6c(cc5c4=O)CCCC6)c3C=O)cn(C)c2=O)nc1
Reaction #606555
122b
Rendement 43.2%DOI: 10.6084/m9.figshare.5104873.v1
CCC1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3cc(F)cc(N4CCc5c(cc6n5CCCC6)C4=O)c3COC(C)=O)cn(C)c2=O)nc1
Reaction #606557
123a
Rendement 53.7%DOI: 10.6084/m9.figshare.5104873.v1
CCC1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3ccnc(N4CCc5c(cc6n5CCCC6)C4=O)c3C=O)cn(C)c2=O)nc1
Reaction #679897
161g
Rendement 57.0%DOI: 10.6084/m9.figshare.5104873.v1
CC[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3C=O)cn(C)c2=O)nc1
Reaction #679905
164a
Rendement 60.0%DOI: 10.6084/m9.figshare.5104873.v1
CC[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3ccnc(-n4ccn5c6c(cc5c4=O)CCCC6)c3C=O)cn(C)c2=O)nc1
Reaction #679907
165a
Rendement 46.0%DOI: 10.6084/m9.figshare.5104873.v1
Cn1cc(-c2ccnc(-n3ncc4c5n(cc4c3=O)CCCC5)c2C=O)cc(Nc2ccc(N3CCN(C4COC4)CC3)cn2)c1=O
Reaction #680020
198a
Rendement 40.8%DOI: 10.6084/m9.figshare.5104873.v1
CCC1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3ccnc(N4CCc5c(cc6n5CCCC6)C4=O)c3C=O)cn(C)c2=O)nc1
Reaction #1108961
161g
Rendement 57.0%DOI: 10.6084/m9.figshare.5104873.v1
CC[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3C=O)cn(C)c2=O)nc1
Reaction #1108969
164a
Rendement 60.0%DOI: 10.6084/m9.figshare.5104873.v1
CC[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3ccnc(-n4ccn5c6c(cc5c4=O)CCCC6)c3C=O)cn(C)c2=O)nc1
Reaction #1108971
165a
Rendement 46.0%DOI: 10.6084/m9.figshare.5104873.v1
Cn1cc(-c2ccnc(N3CCc4c(sc5c4CCCC5)C3=O)c2C=O)cc(Nc2ccc(N3CCN(C4COC4)CC3)cn2)c1=O
Reaction #1108986
169b
Rendement 16.1%DOI: 10.6084/m9.figshare.5104873.v1
Cn1cc(-c2ccnc(-n3ncc4c5n(cc4c3=O)CCCC5)c2C=O)cc(Nc2ccc(N3CCN(C4COC4)CC3)cn2)c1=O
Reaction #1109089
198a
Rendement 40.8%DOI: 10.6084/m9.figshare.5104873.v1
CC[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3cc(F)cc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3COC(C)=O)cn(C)c2=O)nc1
Reaction #1113639
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Rendement 39.0%DOI: 10.6084/m9.figshare.5104873.v1
CC[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3cc(F)cc(-n4ccn5c6c(cc5c4=O)CCCC6)c3C=O)cn(C)c2=O)nc1
Reaction #1113671
122b
Rendement 43.2%DOI: 10.6084/m9.figshare.5104873.v1
CCC1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3cc(F)cc(N4CCc5c(cc6n5CCCC6)C4=O)c3COC(C)=O)cn(C)c2=O)nc1
Reaction #1113673
123a
Rendement 53.7%DOI: 10.6084/m9.figshare.5104873.v1
CC[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3cc(F)cc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3C=O)cn(C)c2=O)nc1
Reaction #1272234
111g
Rendement 35.2%DOI: 10.6084/m9.figshare.5104873.v1
CC[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3ccnc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3C=O)cn(C)c2=O)nc1
Reaction #1272236
112a
Rendement 49.0%DOI: 10.6084/m9.figshare.5104873.v1
CCC1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3ccnc(N4CCc5c(cc6n5CCCC6)C4=O)c3C=O)cn(C)c2=O)nc1
Reaction #1498833
161g
Rendement 57.0%DOI: 10.6084/m9.figshare.5104873.v1
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