Reacción #9996

Ecuación de reacción

2-chloro-9-ethyl-6-(3-trifluoromethyl-phenyl-amino)-9H-purine

3-amino-1-propanol

→

9-Ethyl-2-(3-hydroxy-propyl-amino)-6-(3-trifluoromethyl-phenyl-amino)-9H-purine

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato cool
2. 2
   LavadoThe organic phase is washed with water
3. 3
   Secadodried over sodium sulfate
4. 4
   OtroAfter removal of the solvent
5. 5
   Otrothe residue is recrystallized from ethyl acetate and diethyl ether

Procedimiento

200 mg (0.58 mmol) of 2-chloro-9-ethyl-6-(3-trifluoromethyl-phenyl-amino)-9H-purine and 2 ml of 3-amino-1-propanol are stirred at 140° C. for 2 h and the mixture is allowed to cool and is diluted with 60 ml of ethyl acetate. The organic phase is washed with water and dried over sodium sulfate. After removal of the solvent, the residue is recrystallized from ethyl acetate and diethyl ether. 9-Ethyl-2-(3-hydroxy-propyl-amino)-6-(3-trifluoromethyl-phenyl-amino)-9H-purine is obtained; m.p. 136–137° C.; FAB-MS: (M+H)+=381; Rf=0.7 (ethyl acetate:methanol=9:1).

Fuente