Reacción #998631

Ecuación de reacción

methanesulfonyl chloride

2,2-bis(trifluoromethyl)propanol

triethylamine

→

crude desired intermediate

Rendimiento 101.7%

Methanesulfonic acid 3,3,3-trifluoro-2-methyl-2-trifluoromethyl-propyl ester

Rendimiento 101.7%

Disolventes

water

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextract three times with EtOAc
2. 2
   SecadoDry over anhydrous Na2SO4
3. 3
   Concentraciónconcentrate in vacuo

Procedimiento

To 2,2-bis(trifluoromethyl)propanol (4.34 g, 22.1 mmol) in DCM (100 mL) at 0° C. add with stirring triethylamine (6.2 mL, 44 mmol) followed by methanesulfonyl chloride (2.6 mL, 33 mmol). After 15 min at 0° C. dilute with water and extract three times with EtOAc. Dry over anhydrous Na2SO4 and concentrate in vacuo to give the crude desired intermediate as a yellow oil (6.16 g, 100%).

Fuente