Reacción #998442

Ecuación de reacción

4-cyanophenol

1-bromo-3,3-dimethylbutane

potassium carbonate

potassium iodide

→

desired intermediate

Rendimiento 89.0%

4-(3,3-Dimethylbutoxy)-benzonitrile

Rendimiento 89.0%

Disolventes

acetone

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheat
2. 2
   Temperaturaat reflux for 48 h
3. 3
   Filtraciónfilter
4. 4
   Otroevaporate
5. 5
   OtroPurify by chromatography on silica gel eluting with hexane/EtOAc (10 and 9:1)

Procedimiento

Mix 4-cyanophenol (1.2 g, 10 mmol), 1-bromo-3,3-dimethylbutane (5.3 g, 32 mmol), powdered potassium carbonate (4.14 g, 30 mmol), and powdered potassium iodide (166 mg, 1 mmol) in acetone (60 mL). Stir under inert atmosphere and heat at reflux for 48 h. Cool the reaction mixture to ambient temperature. Dilute with acetone, filter and evaporate. Purify by chromatography on silica gel eluting with hexane/EtOAc (10 and 9:1) to obtain the desired intermediate (1.8 g, 89%). MS (ES+) m/z: 221 (M+NH4)+.

Fuente