Reacción #994

ord-d2aea31453084c8dba037f866c0833b5

Ecuación de reacción

COc1ccccc1C=CCO
2-Methoxy-cinnamylalcohol
O=S(Cl)Cl
thionylchloride
C1CNCCN1
piperazine
COc1ccccc1/C=C/CN1CCN(C/C=C/c2ccccc2OC)CC1
salt
COc1ccccc1/C=C/CN1CCN(C/C=C/c2ccccc2OC)CC1
N,N'-bis-((E)-3-(2-methoxyphenyl)-2-propenyl)piperazine

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otroas described in Preparation Example 2

Procedimiento

2-Methoxy-cinnamylalcohol (1.44 g) was chlorinated using thionylchloride. Subsequently, reaction with piperazine and other treatments were performed as described in Preparation Example 2, to thereby obtain 314 mg of a salt as colorless prisms.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05723465uspto-grants-1998_03