Reacción #992706

Ecuación de reacción

5-aminouracil

4,4′-difluorobenzophenone

→

N-(5-uracil-yl)-4,4′-difluorobenzophenone imine

Disolventes

—

hexanes

N-methylpyrrolidone N-cyclohexylpyrrolidone

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroIn a round bottom flask equipped with an overhead stirrer
2. 2
   workup.ADDITIONwas added to fully induce precipitation
3. 3
   Otrothe solid was isolated by filtration
4. 4
   Otrotwice recrystallized from isopropanol
5. 5
   LavadoThe product was rinsed with isopropanol, suction
6. 6
   Otrodried
7. 7
   Otrovacuum dried in an oven overnight

Procedimiento

In a round bottom flask equipped with an overhead stirrer, 1.16 grams (0.009 mole) of 5-aminouracil was charged along with 6 grams (0.027 mole) of 4,4′-difluorobenzophenone and a N-methylpyrrolidone/N-cyclohexylpyrrolidone solvent mixture (50/50, 20 milliliters). The reaction mixture was then heated to 180° C. for 3 days. A charge of hexanes (100 milliliters) was added to fully induce precipitation, and the solid was isolated by filtration and twice recrystallized from isopropanol. The product was rinsed with isopropanol, suction dried, and vacuum dried in an oven overnight.

Fuente