Reacción #992693

ord-2ba0fedd47514f2ea231865f164fe779

Ecuación de reacción

O=C(O)CC(O)C(=O)O
DL-Malic acid
N=C(N)NN.O=C(O)O
Aminoguanidine bicarbonate
O=C=O
carbon dioxide
→
NNC(N)=[NH2+].NNC(N)=[NH2+].O=C([O-])CC(O)C(=O)[O-]
Bis(aminoguanidinium) DL-Malate

Reactantes

O=C(O)CC(O)C(=O)O
DL-Malic acid
N=C(N)NN.O=C(O)O
Aminoguanidine bicarbonate
O=C=O
carbon dioxide

Reactivos

Ninguno

Disolventes

O
water

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThe water was removed in vacuo
  2. 2
    Temperaturawith heating to approximately 90° C. for 4 hours
  3. 3
    OtroThe product was isolated as a white solid

Procedimiento

DL-Malic acid (2.0 g, 14.92 mmol) was dissolved in 5 ml of distilled water. Aminoguanidine bicarbonate (4.06 g, 29.83 mmol) was added in portions at room temperature (carbon dioxide gas was evolved) and the reaction was stirred at room temperature for 18 hours. The water was removed in vacuo with heating to approximately 90° C. for 4 hours. The product was isolated as a white solid.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08012277B2uspto-grants-2011_09