Reacción #990292

Ecuación de reacción

phosphorus trichloride

hydrochloric acid

chloride

propionyl chloride

propionyl chloride

isobutylbenzene

isobutylbenzene

propionic acid

n-butylbenzene

→

p-isobutylpropiophenone

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Otro3-necked, round bottomed flask there was placed
2. 2
   Temperaturathe resulting solution was cooled to about -5° C. (an ice-methanol bath)
3. 3
   workup.STIRRINGWhile stirring the cooled mixture, 87.50 g
4. 4
   workup.STIRRINGAfter 10 minutes of stirring
5. 5
   Temperaturawhile maintaining the temperature of the mixture at about 0° to 5° C
6. 6
   workup.STIRRINGThe mixture was stirred for an additional 1.25 hours
7. 7
   Otroa reaction as possible and
8. 8
   workup.ADDITIONthen poured into a solution of 250 ml
9. 9
   OtroThe Friedal-Crafts reaction
10. 10
    workup.WAITwas complete in about 45 minutes under these conditions (by GLC analysis)
11. 11
    ExtracciónThe resulting mixture was extracted three times with 300 ml
12. 12
    LavadoThe combined methylene chloride extracts were washed with 250 ml
13. 13
    ExtracciónThe aqueous sodium carbonate extracts were back-extracted with 100 ml
14. 14
    Secadoof methylene chloride and the combined methylene chloride layers were dried over sodium sulfate
15. 15
    ConcentraciónThe dried methylene chloride solution was concentrated under vacuum

Procedimiento

In a 500 ml. 3-necked, round bottomed flask there was placed 25.50 ml. (40.14 g., 0.29 mmole) of phosphorus trichloride and 43.65 ml. (43.34 g., 0.58 mmole) of propionic acid. This mixture was stirred for 2.25 hours under nitrogen atmosphere at room temperature to prepare the propionyl chloride. By NMR propionyl chloride formation was complete in about 1.5 hours. Then 80 ml. of anhydrous methylene chloride was added and the resulting solution was cooled to about -5° C. (an ice-methanol bath). While stirring the cooled mixture, 87.50 g. (0.66 mmole) of alumium chloride (technical grade) was added. After 10 minutes of stirring, 67.11 g. (0.50 mmole) of isobutylbenzene was added dropwise from an addition funnel over 55 minutes while maintaining the temperature of the mixture at about 0° to 5° C. The isobutylbenzene was about 99.6% pure and contained about 0.3% n-butylbenzene. The mixture was stirred for an additional 1.25 hours to insure as complete a reaction as possible and then poured into a solution of 250 ml. of ice water and 150 ml. of concentrated hydrochloric acid with vigorous stirring. The Friedal-Crafts reaction was complete in about 45 minutes under these conditions (by GLC analysis). The resulting mixture was extracted three times with 300 ml. portions of methylene chloride. The combined methylene chloride extracts were washed with 250 ml. of water and three times with 250 ml. of molar concentration aqueous sodium carbonate solution. The aqueous sodium carbonate extracts were back-extracted with 100 ml. of methylene chloride and the combined methylene chloride layers were dried over sodium sulfate. The dried methylene chloride solution was concentrated under vacuum to give crude p-isobutylpropiophenone as a pale yellow oil weighing 97.85 g. By GLC analyses, 3% methylene chloride was present. The chemical yield was about 95 g. or about 100% of theory.

Fuente