Reacción #987617

Ecuación de reacción

4-Methylpyrimidine

Lithium diisopropylamide

N-methoxy-N-methylacetamide

→

(4-Pyrimidyl)acetone

Disolventes

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGThe reaction mixture was stirred at −78° C. for a further 40 minutes
2. 2
   Temperaturato warm to room temperature over 1.25 h
3. 3
   Otropartitioned between saturated aqueous sodium carbonate and ethyl acetate
4. 4
   OtroThe layers were separated
5. 5
   Extracciónthe aqueous phase further extracted with ethyl acetate
6. 6
   LavadoThe combined extracts were washed with brine
7. 7
   Secadodried (MgSO4)
8. 8
   Filtraciónfiltered
9. 9
   Otroevaporated
10. 10
    OtroThe residue was purified by column chromatography on silica gel eluting with 40-50% ethyl acetate in hexane
11. 11
    Otroto give an oil which
12. 12
    Otrocrystallised

Procedimiento

4-Methylpyrimidine (2 g) was stirred in dry tetrahydrofuran (65 ml) under argon and the solution was cooled to −78° C. Lithium diisopropylamide (13.8 ml, 2M solution) was added dropwise over 20 minutes and stirring was continued at −78° C. for 1.5 h before dropwise addition of N-methoxy-N-methylacetamide (2.49 ml). The reaction mixture was stirred at −78° C. for a further 40 minutes before allowing to warm to room temperature over 1.25 h, then partitioned between saturated aqueous sodium carbonate and ethyl acetate. The layers were separated and the aqueous phase further extracted with ethyl acetate. The combined extracts were washed with brine, dried (MgSO4), filtered and evaporated. The residue was purified by column chromatography on silica gel eluting with 40-50% ethyl acetate in hexane to give an oil which crystallised on standing (0.70 g, 24%).

Fuente