Reacción #985327

Ecuación de reacción

2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide

sodium trimethylsilanolate

→

title compound

6-Chloro-1-methylcarbamoylmethyl-1H-indole-3-carboxylic acid

Disolventes

DCE

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónthe mixture was concentrated in vacuo
2. 2
   Otropurified by prep

Procedimiento

2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide was suspended in DCE and treated with (2.2 eq.) of sodium trimethylsilanolate. After shaking at room temperature for 20 min, the mixture was concentrated in vacuo and purified by prep. HPLC to give the title compound.

Fuente