Reacción #985261

Ecuación de reacción

4-nitrobenzoyl chloride

2-aminothiophenol

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product

Rendimiento 73.2%

2-(4-Nitrophenyl)benzothiazole

Rendimiento 73.2%

Disolventes

benzene

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction was quenched with water (20 mL)
2. 2
   OtroThe aqueous layer was separated
3. 3
   Extracciónextracted with ethyl acetate (3×10 ml)
4. 4
   OtroThe combined organic layers were dried
5. 5
   Otroevaporated
6. 6
   OtroThe crude product was purified
7. 7
   Otrowith flush column, (hexane:ethyl acetate=85:15)

Procedimiento

A solution of 4-nitrobenzoyl chloride (1.49 g, 8.0 mmol) in benzene anhydrous, 10 mL) was added dropwise to 2-aminothiophenol (1.0 g, 8.0 mmol in 10 ml of benzene) at room temperature. The reaction mixture was allowed to stir for 16 hr. The reaction was quenched with water (20 mL). The aqueous layer was separated and extracted with ethyl acetate (3×10 ml). The combined organic layers were dried and evaporated. The crude product was purified with flush column, (hexane:ethyl acetate=85:15) to give 1.5 g (73.2%) of product as light yellow solid.

Fuente