Reacción #984630

Ecuación de reacción

3-Amino-4-Cyano-5-(4-phenoxyphenyl)pyrazole

water

formamide

→

pure product

Rendimiento 80.0%

4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine

Rendimiento 80.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooled to 3° C.
2. 2
   Otrothe solid collected
3. 3
   Lavadowashed well with water
4. 4
   Secadomethanol and dried in air

Procedimiento

3-Amino-4-Cyano-5-(4-phenoxyphenyl)pyrazole (Intermediate AB) (29.5 g) was suspended in 300 mL formamide and heated under nitrogen at 180° C. for 4 hours, cooled to 3° C., 300 mL water added and the solid collected, washed well with water then methanol and dried in air giving 24.6 g pure product (80%) of 4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d] pyrimidine m.p. 267-269° C. as pale brown-grey solid. Calculated for C17H13N5O C, 67.3; H, 4.3; N, 23.1; Found C, 67.0; H, 4.4; N, 23.1

Fuente