Reacción #9815

Ecuación de reacción

6-Nitro-2,3-dihydro-benzo[1,4]oxathiine-4,4-dioxide

hydrogen

→

title compound

Rendimiento 46.4%

6-Amino-2,3-dihydro-benzo[1,4]oxathiine-4,4-dioxide

Rendimiento 46.4%

Disolventes

THF

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe catalyst was filtered off
2. 2
   Otrothe filtrate evaporated
3. 3
   Otrothe residue chromatographed on silica

Procedimiento

0.917 g 6-Nitro-2,3-dihydro-benzo[1,4]oxathiine-4,4-dioxide (from g)) were hydrogenated in a mixture of 20 ml THF and 20 ml MeOH with 0.90 g 5% Pd—C at atmospheric hydrogen pressure for 90 min. at room temperature. The catalyst was filtered off, the filtrate evaporated and the residue chromatographed on silica to yield 370 mg of the title compound.

Fuente