Reacción #979954

Ecuación de reacción

3-amino-4-(4-cyanophenyl)amino-2,6-dimethylpyridine

acetic anhydride

→

title compound

Rendimiento 88.0%

1-(4-Cyanophenyl)-2,4,6-trimethylimidazo[4,5-c]pyridine

Rendimiento 88.0%

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe excess of reagents was removed under reduced pressure
2. 2
   workup.DISSOLUTIONthe residual gum was dissolved in water
3. 3
   workup.ADDITIONthe solution was rendered basic by the addition of concentrated aqueous ammonia
4. 4
   OtroThe white solid which precipitated
5. 5
   Filtraciónwas filtered off
6. 6
   Otrodried in vacuo

Procedimiento

A mixture of 3-amino-4-(4-cyanophenyl)amino-2,6-dimethylpyridine (4.20 g, 17.6 mmol), acetic anhydride (12.6 ml) and acetic acid (12.6 ml) was stirred at 100° C. for 16 hours. The excess of reagents was removed under reduced pressure, and the residual gum was dissolved in water and the solution was rendered basic by the addition of concentrated aqueous ammonia. The white solid which precipitated was filtered off and dried in vacuo to give the title compound (4.06 g, 88%), mp 260°-262° C.

Fuente