Reacción #9775

ord-2336788b038b41e689f66b799d3c2b1d

Ecuación de reacción

O=Cc1cscc1-c1ccc(C(F)(F)F)cc1
intermediate 125
O=Cc1cscc1-c1ccc(C(F)(F)F)cc1
4-[4-(trifluoromethyl)phenyl]thiophene-3-carbaldehyde
[Br][Mg][c]1ccccc1
phenyl magnesium bromide
CC(O)c1csc(-c2ccc(C(F)(F)F)cc2)c1
1-{5-[4-(trifluoromethyl)phenyl]thien-3-yl}ethanol
CC(O)c1csc(-c2ccc(C(F)(F)F)cc2)c1
intermediate 126
CC(O)c1csc(-c2ccc(C(F)(F)F)cc2)c1
1-{5-[4-(trifluoromethyl)phenyl]thien-3-yl}ethanol
O=Cc1cscc1-c1ccc(C(F)(F)F)cc1
4-[4-(trifluoromethyl)phenyl]thiophene-3-carbaldehyde
→
OC(c1ccccc1)c1csc(-c2ccc(C(F)(F)F)cc2)c1
title compound
OC(c1ccccc1)c1csc(-c2ccc(C(F)(F)F)cc2)c1
phenyl{5-[4-(trifluoromethyl)phenyl]thien-3-yl}methanol

Reactantes

O=Cc1cscc1-c1ccc(C(F)(F)F)cc1
intermediate 125
O=Cc1cscc1-c1ccc(C(F)(F)F)cc1
4-[4-(trifluoromethyl)phenyl]thiophene-3-carbaldehyde
[Br][Mg][c]1ccccc1
phenyl magnesium bromide
CC(O)c1csc(-c2ccc(C(F)(F)F)cc2)c1
1-{5-[4-(trifluoromethyl)phenyl]thien-3-yl}ethanol
CC(O)c1csc(-c2ccc(C(F)(F)F)cc2)c1
intermediate 126
CC(O)c1csc(-c2ccc(C(F)(F)F)cc2)c1
1-{5-[4-(trifluoromethyl)phenyl]thien-3-yl}ethanol
O=Cc1cscc1-c1ccc(C(F)(F)F)cc1
4-[4-(trifluoromethyl)phenyl]thiophene-3-carbaldehyde

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound was prepared using a method analogous to that used for the preparation of 1-{5-[4-(trifluoromethyl)phenyl]thien-3-yl}ethanol (intermediate 126) using 4-[4-(trifluoromethyl)phenyl]thiophene-3-carbaldehyde (intermediate 125) and phenyl magnesium bromide.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07091237B2uspto-grants-2006_08