Reacción #974782

Ecuación de reacción

4-methylpyrimidine

HCl

ethyl nitrite

→

titled compound

Pyrimidine-4-carbaldehyde Oxime

Disolventes

EtOH

EtOH

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONTo this white suspension was added, over 5 min
2. 2
   workup.WAITat RT for 2.5 h
3. 3
   FiltraciónThe white salt was filtered
4. 4
   Otrodried under vacuum
5. 5
   workup.DISSOLUTIONThe salt was dissolved into 20 ml H2O
6. 6
   workup.ADDITIONvery slowly treated with about 200 ml saturated aqueous KHCO3
7. 7
   OtroA white solid precipitated out of the purple solution
8. 8
   FiltraciónThe solid was filtered
9. 9
   Otrodried under vacuum

Procedimiento

9.14 g (97.11 mmol) of 4-methylpyrimidine was slowly added to a 0° C. solution of 8.75 g HCl in 40 ml EtOH. To this white suspension was added, over 5 min, 61 ml of a 10-20% by weight solution of ethyl nitrite in EtOH. The reaction was stirred at 0° C. for 10 min and then at RT for 2.5 h. The white salt was filtered and dried under vacuum. The salt was dissolved into 20 ml H2O and very slowly treated with about 200 ml saturated aqueous KHCO3. A white solid precipitated out of the purple solution. The solid was filtered and dried under vacuum to yield the titled compound.

Fuente