Reacción #9726

Ecuación de reacción

4-(hydroxymethyl)-2,6-dimethylphenol

ethyl bromoacetate

caesium carbonate

→

title compound

ethyl[4-(hydroxymethyl)-2,6-dimethylphenoxy]acetate

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe solution was concentrated
2. 2
   Otrothe residue partitioned between ethyl acetate and water
3. 3
   OtroThe organic layer was collected
4. 4
   Secadodried over magnesium sulfate
5. 5
   Filtraciónfiltered
6. 6
   ConcentraciónThe filtrate was concentrated

Procedimiento

A solution of 4-(hydroxymethyl)-2,6-dimethylphenol (P. Claus et al., Monatsh. Chem. 1972, 103(4), 1178–1193) (1.9 g) in acetonitrile (50 ml) was treated with ethyl bromoacetate (2.17 g) and caesium carbonate (4.24 g) and the mixture stirred at room temperature overnight. The solution was concentrated and the residue partitioned between ethyl acetate and water. The organic layer was collected, dried over magnesium sulfate and filtered. The filtrate was concentrated to give the title compound as a yellow oil.

Fuente