Reacción #972274

Ecuación de reacción

4,4′-dihydroxystilbene

→

4-[4-Hydroxy-phenethyl]-phenol

Rendimiento 97.1%

Disolventes

MeOH

EtOAc

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe catalyst was removed by filtration
2. 2
   Concentraciónthe filtrate was concentrated
3. 3
   OtroChromatography purification of the crude product on silica gel (hexane-EtOAc 3:1, 2:1)

Procedimiento

A solution of 4,4′-dihydroxystilbene (250 mg, 1.178 mmol) in MeOH (10 mL) and EtOAc (2 mL) containing 5% Pd—C (120 mg) was stirred under an atmosphere of hydrogen for 2 h. The catalyst was removed by filtration and the filtrate was concentrated. Chromatography purification of the crude product on silica gel (hexane-EtOAc 3:1, 2:1) provided 245 mg of 4-[4-Hydroxy-phenethyl]-phenol (97%) as a white solid. MS (ES) m/z: 213.05 (M−1).

Fuente