Reacción #9720

Ecuación de reacción

1-(4-Hydroxy-3-methylphenyl)ethanone

cesium carbonate

ethyl bromoacetate

cesium carbonate

Ethyl bromoacetate

→

title compound

ethyl(4-acetyl-2-methylphenoxy)acetate

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheating
2. 2
   workup.WAITcontinued for a further hour
3. 3
   OtroThe cooled reaction
4. 4
   Filtraciónwas filtered
5. 5
   Concentraciónthe filtrate concentrated

Procedimiento

1-(4-Hydroxy-3-methylphenyl)ethanone (90 g) and cesium carbonate (216 g) were stirred in acetonitrile (900 ml) at room temperature under nitrogen for 10 minutes. Ethyl bromoacetate (73 ml) was added and the mixture heated to 40° C. for 3 hours. Further ethyl bromoacetate (2.5 ml) and cesium carbonate (1 g) were added and heating continued for a further hour. The cooled reaction was filtered and the filtrate concentrated to give the title compound as a yellow oil.

Fuente