Reacción #9719

Ecuación de reacción

2-trifluoromethylphenol

cesium carbonate

ethyl bromoacetate

→

title compound

ethyl[2-(trifluoromethyl)phenoxy]acetate

Disolventes

acetonitrile

water

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadothe organic layer washed with water
2. 2
   Secadodried with brine and over sodium sulfate
3. 3
   OtroEvaporation of ethyl acetate

Procedimiento

A mixture of 2-trifluoromethylphenol (1.62 g) in anhydrous acetonitrile was treated with cesium carbonate (3.25 g) and ethyl bromoacetate (1.75 g) and the reaction mixture stirred at room temperature for 2 hours. The reaction mixture was diluted with water and ethyl acetate and the organic layer washed with water and dried with brine and over sodium sulfate. Evaporation of ethyl acetate gave the title compound as a colourless oil.

Fuente