Reacción #9708

Ecuación de reacción

NaOH

NaHCO3

N-(4-iodophenyl)-6-methyl-1,3-benzothiazol-2-amine

methyl trans-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl]cyclopentanecarboxylate

dichloromethane

→

trans-2-({4′-[(6-methyl-1,3-benzothiazol-2-yl)amino]-1,1′-biphenyl-4-yl}carbonyl)-cyclopentanecarboxylic acid

Rendimiento 74.0%

Disolventes

EtOH

Toluene

EtOAc

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe resulting solution was degassed
2. 2
   Otroby bubbling a flow of argon for 30 minutes
3. 3
   Filtraciónfiltered through a Celite® pad
4. 4
   OtroThe solvent was removed by rotary evaporation
5. 5
   ConcentraciónThe reaction mixture was concentrated under reduced pressure
6. 6
   workup.ADDITIONConcentrated HCl was added
7. 7
   Extracciónthe suspension was extracted with EtOAc
8. 8
   LavadoThe combined organic phases were washed with brine
9. 9
   Secadodried over sodium sulfate
10. 10
    Concentraciónconcentrated in vacuo
11. 11
    Filtraciónthe precipitate was collected by filtration
12. 12
    Lavadowashed with EtOAc, MeOH, and DCM
13. 13
    Otrodried in a vacuum oven

Procedimiento

N-(4-iodophenyl)-6-methyl-1,3-benzothiazol-2-amine (0.28 g, 0.78 mmol) and methyl trans-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl]cyclopentanecarboxylate (0.25 g, 0.71 mmol) were combined in a dry flask under argon. Toluene (15 mL), EtOH (6 mL), and saturated aqueous NaHCO3 (2 mL) were then added, and the resulting solution was degassed by bubbling a flow of argon for 30 minutes. Then [1,1′-bis(diphenylphosphino)-ferrocene]dichloro-palladium (II), complex with dichloromethane (1:1) (57 mg, 0.07 mmol) was added, and the resulting mixture was heated at 85° C. for 16 h. The reaction mixture was then diluted with EtOAc and filtered through a Celite® pad. The solvent was removed by rotary evaporation and the residue was brought up in MeOH. Then 1 N aqueous NaOH (2.0 mL, 2.0 mmol) was added to the suspension, and the reaction mixture was stirred at 50° C. overnight. The reaction mixture was concentrated under reduced pressure and the residue was suspended in water. Concentrated HCl was added to adjust the acidity to pH 1, and the suspension was extracted with EtOAc. The combined organic phases were washed with brine, dried over sodium sulfate, passed through a pad of silica gel, and concentrated in vacuo. The residue was brought up in EtOAc and the precipitate was collected by filtration, washed with EtOAc, MeOH, and DCM, and dried in a vacuum oven to afford trans-2-({4′-[(6-methyl-1,3-benzothiazol-2-yl)amino]-1,1′-biphenyl-4-yl}carbonyl)-cyclopentanecarboxylic acid (0.24 g, 19%). LC-MC ret. time 3.57; m/z 457.3 (MH+); 1H NMR (400 MHz, DMSO-d6) δ 1.57–1.86 (m, 4H), 2.00 (m, 1H), 2.17 (m, 1H), 2.37 (s, 3H), 3.22 (q, 1H), 4.08 (q, 1H), 7.14 (m, 1H), 7.51 (d, 1H), 7.61 (s, 1H), 7.80 (m, 3H), 7.89 (d, 2H), 8.05 (d, 2H), 10.58 (s, 1H), 12.19 (s, 1H).

Fuente