Reacción #970455

Ecuación de reacción

HCl

(2R)-dimethyl-[5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-naphthalen-2-yl]amine

→

title product

Rendimiento 99.0%

(2R)-Dimethyl-[5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-amine dihydrochloride

Rendimiento 99.0%

Disolventes

Et2O

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónthe solvent was concentrated off
2. 2
   Concentraciónconcentrated, in order
3. 3
   Otroto remove excess of HCl

Procedimiento

HCl (9.2 mL, 4 M solution in dioxane, 18.51 mmol) was dropwise added to a suspension of (2R)-dimethyl-[5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-naphthalen-2-yl]amine (1.75 g, 6.17 mmol) in Et2O (10 mL). The reaction mixture was stirred at room temperature for 3 h and then the solvent was concentrated off. The resulting solid was suspended in Et2O (25 mL) and concentrated, in order to remove excess of HCl. This operation was done for three times, to give 1.95 g of the title product (Rf=0.2 (10% Et3N/AcOEt), white solid, 99% yield).

Fuente